The Chicago Bears (11-4) visit the San Francisco 49ers (11-4) at Levi's Stadium in Santa Clara for a Week 17 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff on Sunday, December 28, including live updated odds and injury report news.
| Name | Week 16 | 2025 Season |
|---|---|---|
| Blake Schuster | 12-3-1 | 127-94-6 |
| Jon Hoefling | 8-7-1 | 117-117-6 |
| Tyler Dragon | 6-9-1 | 116-118-6 |
| Chris Bumbaca | 8-7-1 | 101-104-5 |
| Lorenzo Reyes | N/A | 107-112-5 |
| Jordan Mendoza | 11-4-1 | 98-107-5 |
| Richard Morin | 10-5-1 | 47-34-3 |
49ers vs. Bears live odds, moneyline, over/under
Opening Lines
- Spread: 49ers (-3.5)
- Moneyline: 49ers (-192), Bears (+164)
- Over/Under: 46.5
Get the edge with our exclusive NFL betting picks
49ers vs. Bears picks against the spread
Jordan Mendoza: San Francisco 49ers (-3)
Chicago is so close to capturing the NFC North, but it's no easy task to go into the Bay Area and face a 49ers team that is clicking on all cylinders. San Francisco stays in the conversation for a division title.
Tyler Dragon: Chicago Bears (+3)
Ben Johnson and Kyle Shanahan deserve coach of the year consideration. This is a pick 'em game, but the Bears have found ways to win all season.
Blake Schuster: Chicago Bears (+3)
Chicago got a little extra rest but San Francisco gets the benefit of playing at home. A one-possession game feels right. Take the points.
Jon Hoefling: San Francisco 49ers (-3)
Caleb Williams' best tool is his improvisation. Too bad the Niners don't have a pass rush to improvise against.
Lorenzo Reyes: San Francisco 49ers (-3)
The 49ers have the more complete roster and are playing on an absolute tear behind Brock Purdy, Christian McCaffrey and George Kittle. The Bears have been excellent, but against solid teams, they tend to play close. At home, I like the Niners in this spot.
Christopher Bumbaca: San Francisco 49ers (-3)
This is my fade the public spot of the week. The public will be all over the Bears, so I'll go with a team that might still be playing for a division title, or perhaps the No. 1 seed.
49ers vs. Bears updated injury report
NFL Week 17 picks, predictions, odds
- Cowboys at Commanders
- Lions at Vikings
- Broncos at Chiefs
- Texans at Chargers
- Ravens at Packers
- Seahawks at Panthers
- Jaguars at Colts
- Saints at Titans
- Cardinals at Bengals
- Steelers at Browns
- Patriots at Jets
- Buccaneers at Dolphins
- Giants at Raiders
- Eagles at Bills
- Bears at 49ers
- Rams at Falcons
